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Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp Acta 2930

Lookup NU author(s): Professor Michael Goodfellow

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Abstract

A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 20 NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.

Publication metadata

Author(s): Helaly SE, Goodfellow M, Zinecker H, Imhoff JF, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2013

Volume: 66

Issue: 11

Pages: 669-674

Print publication date: 01/11/2013

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2013.74

DOI: 10.1038/ja.2013.74

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