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Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38

Lookup NU author(s): Professor Alan Bull, Professor Michael Goodfellow

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Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells. The Journal of Antibiotics (2011) 64, 775-780; doi: 10.1038/ja.2011.96; published online 19 October 2011

Publication metadata

Author(s): Nachtigall J, Kulik A, Helaly S, Bull AT, Goodfellow M, Asenjo JA, Maier A, Wiese J, Imhoff JF, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2011

Volume: 64

Issue: 12

Pages: 775-780

Print publication date: 01/12/2011

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2011.96

DOI: 10.1038/ja.2011.96

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