Browse by author
Lookup NU author(s): Dr Christopher Morris
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance has been strongly implicated as a cause of disease. Thus, understanding tau isoform regional expression in disease and pathology-free states is crucial to elucidating the mechanisms involved in PSP and other tauopathies. We used a tau isoform-specific fluorescent assay to investigate relative 4R-tau expression in 6 different brain regions in PSP cases and healthy control samples. We identified a marked difference in 4R-tau relative expression, across brain regions and between MAPT haplotypes. Highest 4R-tau expression levels were identified in the globus pallidus compared with pons, cerebellum, and frontal cortex. 4R-tau expression levels were related to the MAPT H1 and H1c haplotypes. Similar regional variation was seen in PSP case and in control samples. (C) 2013 Elsevier Inc. All rights reserved.
Author(s): Majounie E, Cross W, Newsway V, Dillman A, Vandrovcova J, Morris CM, Nalls MA, Ferrucci L, Owen MJ, O'Donovan MC, Cookson MR, Singleton AB, de Silva R, Morris HR
Publication type: Article
Publication status: Published
Journal: Neurobiology of Aging
Year: 2013
Volume: 34
Issue: 7
Pages: 1922.e7-1922.e12
Print publication date: 01/07/2013
Online publication date: 19/02/2013
Acceptance date: 22/01/2013
ISSN (print): 0197-4580
ISSN (electronic): 1558-1497
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.neurobiolaging.2013.01.017
DOI: 10.1016/j.neurobiolaging.2013.01.017
Altmetrics provided by Altmetric
