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Lookup NU author(s): Dr Rob ForsythORCiD
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Objectives: To describe current patterns of management of raised intracranial pressure (ICP) in traumatic brain injury relevant to clinician buy-in to possible randomized controlled trials of treatments of raised ICP. To examine the feasibility of early identification of children at sufficient risk of developing raised ICP to permit a uniform approach between centers to the initiation of ICP monitoring. This would permit quantification of ICP elevation and enrollment as appropriate to randomized controlled trials of raised ICP interventions. Design: Logistic regression modeling of death before pediatric intensive care unit discharge and decision tree and logistic regression of development of raised ICP through analysis of a prospectively collected, standardized, national data set. Setting: Pediatric intensive care units in the United Kingdom and Eire. Patients: Patients were 501 children <16 yrs of age primarily admitted to intensive care unit for management of traumatic brain injury in the United Kingdom and Eire between February 2001 and August 2003. Interventions: None. Measurements and Main Results: The data analyzed included demographic, acute physiologic, and cranial imaging variables. Death was associated with both raised ICP and the nonmeasurement of ICP. In a subset of 199 patients, an empirically derived decision rule predicted the development of raised ICP at any point during ICU admission with sensitivity of 73% and specificity of 74% (positive predictive value 82% and negative predictive value 63%). Logistic regression modeling performed comparably. The decision rule also predicted raised ICP in 20% of children not undergoing ICP monitoring. Conclusions: Simple models based on early clinical data may predict the development of raised ICP sufficiently well to encourage a consistent approach between centers to initiation of ICP monitoring. We estimate studies designed to detect reductions in ICU mortality will require >320 children per arm, although this figure may be higher if more conservative assumptions are made.
Author(s): Forsyth RJ, Parslow RC, Tasker RC, Hawley C, Morris KP
Publication type: Article
Publication status: Published
Journal: Pediatric Critical Care Medicine
Year: 2008
Volume: 9
Issue: 1
Pages: 8-14
ISSN (print): 1529-7535
ISSN (electronic): 1947-3893
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1097/01.PCC.0000298759.78616.3A
DOI: 10.1097/01.PCC.0000298759.78616.3A
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