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Diabetes Mellitus and Inflammation

Lookup NU author(s): Dr Eugene Sobngwi

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Abstract

Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.

Publication metadata

Author(s): Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP

Publication type: Article

Publication status: Published

Journal: Current Diabetes Reports

Year: 2013

Volume: 13

Issue: 3

Pages: 435-444

Print publication date: 01/06/2013

Online publication date: 14/03/2013

ISSN (print): 1534-4827

ISSN (electronic): 1539-0829

Publisher: Springer Healthcare

URL: http://dx.doi.org/10.1007/s11892-013-0375-y

DOI: 10.1007/s11892-013-0375-y

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