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Lookup NU author(s): Professor Alan Boddy
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Introduction: Pharmacokinetic (PK) studies for long-established drugs are generally performed outside the well-standardized settings of pharmaceutical industry trials. Instead, such studies are usually performed within daily clinical practice of hospitals.Areas covered: This article describes aspects of intravenous (i.v.) drug administration and blood sampling that contribute to potential sources of preanalytical errors for PK investigations. Parameters that bias determination of start and end time of i.v. infusions, as well as consistent rate of drug delivery, are discussed. Causes for drug loss in the infusion device, including adsorption and insufficient flushing, are outlined. The advantages and disadvantages of different blood sampling techniques are reviewed, with an emphasis on pediatric studies.Expert opinion: For PK studies that are integrated into the general hospital routine, a variety of potential sources of error exist. Potential pitfalls depend on the specific drug and trial characteristics and they must be anticipated and discussed in advance. Working procedures need to be developed that address the anticipated problems and in detail describe procedures that need compliance between bed and bench.
Author(s): Krischke M, Boddy AV, Boos J
Publication type: Review
Publication status: Published
Journal: Expert Opinion on Drug Metabolism & Toxicology
Print publication date: 01/06/2014
ISSN (print): 1742-5255
ISSN (electronic): 1744-7607
Publisher: INFORMA HEALTHCARE