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Lookup NU author(s): Dr Ahmed Khudhur,
Professor Marco Carrozzo
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The concept of lichenoid tissue reaction/interface dermatitis was introduced in dermatology to define a number of diverse inflammatory skin diseases linked together by the presence of common histopathological features. Similarly to the skin, the oral mucosa is affected by a variety of oral lichenoid lesions. Oral LTRs (OLTRs) include: oral lichen planus; oral lichenoid contact lesion; oral lichenoid drug reaction; oral lichenoid lesions of graft-versus-host disease; oral discoid lupus erythematosus; oral lesions of systemic lupus erythematosus; erythema multiforme; paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome; chronic ulcerative stomatitis and lichen planus pemphigoid. Traditionally, diagnosis of OLTRs relies on clinical and histological correlation but in several instances this approach fails to provide a reliable diagnosis. Inclusion of molecular techniques may refine our ability to differentiate OLTRs.
Author(s): Khudhur AS, Di Zenzo G, Carrozzo M
Publication type: Review
Publication status: Published
Journal: Expert Review of Molecular Diagnostics
Print publication date: 01/03/2014
ISSN (print): 1473-7159
ISSN (electronic): 1744-8352
Publisher: EXPERT REVIEWS