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Oral lichenoid tissue reactions: diagnosis and classification

Lookup NU author(s): Dr Ahmed Khudhur, Professor Marco Carrozzo


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The concept of lichenoid tissue reaction/interface dermatitis was introduced in dermatology to define a number of diverse inflammatory skin diseases linked together by the presence of common histopathological features. Similarly to the skin, the oral mucosa is affected by a variety of oral lichenoid lesions. Oral LTRs (OLTRs) include: oral lichen planus; oral lichenoid contact lesion; oral lichenoid drug reaction; oral lichenoid lesions of graft-versus-host disease; oral discoid lupus erythematosus; oral lesions of systemic lupus erythematosus; erythema multiforme; paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome; chronic ulcerative stomatitis and lichen planus pemphigoid. Traditionally, diagnosis of OLTRs relies on clinical and histological correlation but in several instances this approach fails to provide a reliable diagnosis. Inclusion of molecular techniques may refine our ability to differentiate OLTRs.

Publication metadata

Author(s): Khudhur AS, Di Zenzo G, Carrozzo M

Publication type: Review

Publication status: Published

Journal: Expert Review of Molecular Diagnostics

Year: 2014

Volume: 14

Issue: 2

Pages: 169-184

Print publication date: 01/03/2014

ISSN (print): 1473-7159

ISSN (electronic): 1744-8352



DOI: 10.1586/14737159.2014.888953