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Lookup NU author(s): Dr Michael FirbankORCiD, Professor John O'Brien, Dr Dag Aarsland
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White matter changes (WMC) are the focus of intensive research and have been linked to cognitive impairment and depression in the elderly. Cumbersome manual outlining procedures make research on WMC labor intensive and prone to subjective bias. We present a fast, fully automated method for WMC segmentation using a cascade of reduced support vector machines (SVMs) with active learning. Data of 102 subjects was used in this study. Two MRI sequences (T1-weighted and FLAIR) and masks of manually outlined WMC from each subject were used for the image analysis. The segmentation framework comprises pre-processing, classification (training and core segmentation) and post-processing. After pre-processing, the model was trained on two subjects and tested on the remaining 100 subjects. The effectiveness and robustness of the classification was assessed using the receiver operating curve technique. The cascade of SVMs segmentation framework outputted accurate results with high sensitivity (90%) and specificity (99.5%) values, with the manually outlined WMC as reference. An algorithm for the segmentation of WMC is proposed. This is a completely competitive and fast automatic segmentation framework, capable of using different input sequences, without changes or restrictions of the image analysis algorithm. (C) 2012 Elsevier B.V. All rights reserved.
Author(s): Damangir S, Manzouri A, Oppedal K, Carlsson S, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK, Westman E, Aarsland D, Wahlund LO, Spulber G
Publication type: Article
Publication status: Published
Journal: Journal of the Neurological Sciences
Year: 2012
Volume: 322
Issue: 1-2
Pages: 211-216
Print publication date: 15/11/2012
Online publication date: 23/08/2012
Acceptance date: 26/07/2012
ISSN (print): 0022-510X
ISSN (electronic): 1878-5883
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.jns.2012.07.064
DOI: 10.1016/j.jns.2012.07.064
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