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The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Lookup NU author(s): Professor Graham Jackson

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Abstract

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

Publication metadata

Author(s): Weinhold N, Johnson DC, Chubb D, Chen BW, Forsti A, Hosking FJ, Broderick P, Ma YP, Dobbins SE, Hose D, Walker BA, Davies FE, Kaiser MF, Li NL, Gregory WA, Jackson GH, Witzens-Harig M, Neben K, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Ross FM, Jauch A, Goldschmidt H, Houlston RS, Morgan GJ, Hemminki K

Publication type: Letter

Publication status: Published

Journal: Nature Genetics

Year: 2013

Volume: 45

Issue: 5

Pages: 522-525

Print publication date: 01/05/2013

Online publication date: 17/03/2013

Acceptance date: 21/02/2013

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: NATURE PUBLISHING GROUP

URL: http://dx.doi.org/10.1038/ng.2583

DOI: 10.1038/ng.2583

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