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Lookup NU author(s): Professor Graham Jackson
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A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
Author(s): Weinhold N, Johnson DC, Chubb D, Chen BW, Forsti A, Hosking FJ, Broderick P, Ma YP, Dobbins SE, Hose D, Walker BA, Davies FE, Kaiser MF, Li NL, Gregory WA, Jackson GH, Witzens-Harig M, Neben K, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Ross FM, Jauch A, Goldschmidt H, Houlston RS, Morgan GJ, Hemminki K
Publication type: Letter
Publication status: Published
Journal: Nature Genetics
Year: 2013
Volume: 45
Issue: 5
Pages: 522-525
Print publication date: 01/05/2013
Online publication date: 17/03/2013
Acceptance date: 21/02/2013
ISSN (print): 1061-4036
ISSN (electronic): 1546-1718
Publisher: NATURE PUBLISHING GROUP
URL: http://dx.doi.org/10.1038/ng.2583
DOI: 10.1038/ng.2583