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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

Lookup NU author(s): Professor Graham Jackson


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To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

Publication metadata

Author(s): Broderick P, Chubb D, Johnson DC, Weinhold N, Forsti A, Lloyd A, Olver B, Ma YP, Dobbins SE, Walker BA, Davies FE, Gregory WA, Child JA, Ross FM, Jackson GH, Neben K, Jauch A, Hoffmann P, Muhleisen TW, Nothen MM, Moebus S, Tomlinson IP, Goldschmidt H, Hemminki K, Morgan GJ, Houlston RS

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2012

Volume: 44

Issue: 1

Pages: 58-61

Print publication date: 01/01/2012

Online publication date: 27/11/2011

Acceptance date: 03/10/2011

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group


DOI: 10.1038/ng.993


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Funder referenceFunder name
Bobby Moore Fund
German Ministry of Education and Science
German Centre for Neurodegenerative Disorders (DZNE), Bonn
Heinz-Nixdorf Foundation
Leukaemia Lymphoma Research Fund
Myeloma UK
National Health Services (NHS) through the Biological Research Centre of the National Institute for Health Research at the Royal Marsden Hospital NHS Trust
C1298/A8362Cancer Research UK
ER 155/6-1German Research Council (DFG)
Health-F4-2007-200767APO-STS (European Union)
SI 236/8-1German Research Council (DFG)
SI236/9-1German Research Council (DFG)