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Changes in fetal prevalence and outcome for trisomies 13 and 18: a population-based study over 23 years

Lookup NU author(s): Dr Sam Richmond, Dr Christopher Wren, Professor Nicholas Embleton

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Abstract

Objective. Changes in prenatal diagnosis and maternal age are likely to have an impact on live born prevalence of trisomies 13 and 18. We investigated trends in diagnosis, prevalence, and survival in these conditions.Methods. A population-based study of one UK health region in 1985-2007 using a well-established congenital abnormality register. Individual records were reviewed and live birth and maternal age data obtained.Results. Pregnancies with trisomies 13 and 18 increased from 0.08 to 0.23 per 1000 registered births and 0.20 to 0.65 per 1000 registered births, respectively. Prenatal diagnosis increased and was associated with high termination rates. Live born prevalence with trisomy 13 decreased from 0.05 to 0.03 per 1000 live births and with trisomy 18 from 0.16 to 0.10 per 1000 live births. Postnatal survival remains poor: one baby (3%) with trisomy 13 and four (6%) with trisomy 18 survived the first year. The percentage of mothers over 35 years increased from 6 to 15%.Conclusions. Changes in prenatal screening and maternal age have had dramatic effects on the live born prevalence of trisomies 13 and 18. Infant survival remains largely unchanged with the majority dying in the neonatal period.


Publication metadata

Author(s): Irving C, Richmond S, Wren C, Longster C, Embleton ND

Publication type: Article

Publication status: Published

Journal: Journal of Maternal-Fetal and Neonatal Medicine

Year: 2011

Volume: 24

Issue: 1

Pages: 137-141

Print publication date: 01/01/2011

ISSN (print): 1476-7058

ISSN (electronic): 1476-4954

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/14767051003758879

DOI: 10.3109/14767051003758879


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