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The neonatal bowel microbiome in health and infection

Lookup NU author(s): Dr Janet Berrington, Dr Christopher StewartORCiD, Professor Nicholas EmbletonORCiD


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Purpose of review There is a need for improved diagnosis and for optimal classification of patients with infectious diseases. An alternative approach to the pathogen-detection strategy is based on a comprehensive analysis of the host response to the infection. This review focuses on the value of transcriptome analyses of blood leukocytes for the diagnosis and management of patients with infectious diseases. Recent findings Initial studies showed that RNA from blood leukocytes of children with acute viral and bacterial infections carried pathogen-specific transcriptional signatures. Subsequently, transcriptional signatures for several other infections have been described and validated in humans with malaria, dengue, salmonella, melioidosis, respiratory syncytial virus, influenza, tuberculosis, and HIV. In addition, transcriptome analyses represent an invaluable tool to understand disease pathogenesis and to objectively classify patients according to the clinical severity. Microarray studies have been shown to be highly reproducible using different platforms, and in different patient populations, confirming the value of blood transcriptome analyses to study pathogen-specific host immune responses in the clinical setting. Combining the detection of the pathogen with a comprehensive assessment of the host immune response will provide a new understanding of the correlations between specific causative agents, the host response, and the clinical manifestations of the disease.

Publication metadata

Author(s): Berrington JE, Stewart CJ, Cummings SP, Embleton ND

Publication type: Review

Publication status: Published

Journal: Current Opinion in Infectious Diseases

Year: 2014

Volume: 27

Issue: 3

Pages: 236-243

Print publication date: 01/06/2014

Acceptance date: 01/01/1900

ISSN (print): 0951-7375

ISSN (electronic): 1473-6527



DOI: 10.1097/QCO.0000000000000065

PubMed id: 24751892