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The use of rpoB sequence analysis in the differentiation of Mycobacterium abscessus and Mycobacterium chelonae: a critical judgement in cystic fibrosis?

Lookup NU author(s): Professor John Magee

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Abstract

Individuals suffering from fibrocystic disease may acquire non-tuberculous mycobacteria as colonizing or infecting organisms. Mycobacterium abscessus is of particular concern because it may be very difficult to eradicate and may mitigate against lung transplantation. However, this species may be difficult to reliably differentiate from the closely related M. chelonae. We have developed a rapid, low-cost, short sequence-based technique to confirm species identity by analysis of a segment of the RNA Polymerase B (rpoB) gene.

Publication metadata

Author(s): Arnold C, Barrett A, Cross L, Magee JG

Publication type: Article

Publication status: Published

Journal: Clinical Microbiology and Infection

Year: 2012

Volume: 18

Issue: 5

Pages: E131-E133

Print publication date: 16/03/2012

ISSN (print): 1198-743X

ISSN (electronic): 1469-0691

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/j.1469-0691.2012.03785.x

DOI: 10.1111/j.1469-0691.2012.03785.x

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