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Lookup NU author(s): Emeritus Professor Nick Europe-Finner
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Background: Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure.Methods: Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids >= 200 mu g beclomethasone or equivalent + long-acting-beta(2)-agonists and demonstrated worsening of asthma on long-acting-beta(2)-agonist withdrawal. Following initial evaluation at 1 year, subjects were invited to participate in a 4 year safety study. Adverse events (AEs) and spirometry data were used to assess long-term safety out to 5 years post-BT.Results: 45 of 52 treated and 24 of 49 control group subjects participated in long-term follow-up of 5 years and 3 years respectively. The rate of respiratory adverse events (AEs/subject) was stable in years 2 to 5 following BT (1.2, 1.3, 1.2, and 1.1, respectively,). There was no increase in hospitalizations or emergency room visits for respiratory symptoms in Years 2, 3, 4, and 5 compared to Year 1. The FVC and FEV1 values showed no deterioration over the 5 year period in the BT group. Similar results were obtained for the Control group.Conclusions: The absence of clinical complications (based on AE reporting) and the maintenance of stable lung function (no deterioration of FVC and FEV1) over a 5-year period post-BT in this group of patients with moderate to severe asthma support the long-term safety of the procedure out to 5 years.
Author(s): Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Laviolette M, Shargill NS, Cox G, AIR Trial Study Group
Publication type: Article
Publication status: Published
Journal: BMC Pulmonary Medicine
Online publication date: 11/02/2011
Acceptance date: 11/02/2011
Date deposited: 10/12/2015
ISSN (electronic): 1471-2466
Publisher: BioMed Central Ltd.
PubMed id: 21314924
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