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The role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies

Lookup NU author(s): Professor Andrew GenneryORCiD


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The advent of reprogramming technology has greatly advanced the field of stem cell biology and nurtured our hope to create patient specific renewable stem cell sources. While the number of reports of disease specific induced pluripotent stem cells is continuously rising, the field becomes increasingly more aware that induced pluripotent stem cells are not as similar to embryonic stem cells as initially assumed. Our state of the art understanding of human induced pluripotent stem cells, their capacity, their limitations and their promise as it pertains to the study and treatment of primary immunodeficiencies, is the content of this review.

Publication metadata

Author(s): Weinacht KG, Brauer PM, Felgentreff K, Devine A, Gennery AR, Giliani S, Al-Here W, Schambach A, Zuniga-Pflucker JC, Notarangelo LD

Publication type: Review

Publication status: Published

Journal: Current Opinion in Immunology

Year: 2012

Volume: 24

Issue: 5

Pages: 617-624

Print publication date: 25/07/2012

ISSN (print): 0952-7915

ISSN (electronic): 1879-0372



DOI: 10.1016/j.coi.2012.07.001