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Advances in hematopoietic stem cell transplantation for primary immunodeficiency

Lookup NU author(s): Dr Mary Slatter, Professor Andrew GenneryORCiD

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Abstract

The transplantation of hematopoietic stem cells in patients with primary immunodeficiencies has improved significantly over the last 40 years. In favorable circumstances when there is minimal or no infection present, no end-organ damage and the availability of a well HLA-matched donor, survival and cure reaches 90%. Barriers to further success include late identification of disease, with accumulation of infection- and inflammation-related organ damage, stem cell manipulation when there is no HLA-matched donor, toxicity of conditioning regimens and prediction and treatment of graft-versus-host disease. This review will outline recent developments in conditioning regimens, stem cell source manipulation and early detection and treatment of graft-versus-host disease, with a particular emphasis on patients with primary immunodeficiency.


Publication metadata

Author(s): Slatter MA, Gennery AR

Publication type: Review

Publication status: Published

Journal: Expert Review of Clinical Immunology

Year: 2013

Volume: 9

Issue: 10

Pages: 991-999

Print publication date: 01/10/2013

ISSN (print): 1744-666X

ISSN (electronic): 1744-8409

Publisher: EXPERT REVIEWS

URL: http://dx.doi.org/10.1586/1744666X.2013.836061

DOI: 10.1586/1744666X.2013.836061


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