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Pharmacologic Biomarkers in the Development of Stratified Cancer Medicine

Lookup NU author(s): Professor Herbie Newell

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Abstract

Clinical pharmacologic research plays a vital role in cancer drug development. In recent years, biomarker studies have become integral to this process, specifically the use of pharmacologic biomarkers in the development of targeted therapies and their translation to clinical practice. In this overview, we discuss the validation of pharmacodynamics (PD) biomarkers and highlight the circulating tumor DNA as a promising cancer biomarker to illustrate how PD 'biomarkers can be powerful tools for guiding treatment strategies. We provide insights into PD biomarker approaches for future development of novel therapies and their role in cancer medicine. (C) 2014 AACR.

Publication metadata

Author(s): Figg WD, Newell DR

Publication type: Article

Publication status: Published

Journal: Clinical Cancer Research

Year: 2014

Volume: 20

Issue: 10

Pages: 2525-2529

Print publication date: 15/05/2014

ISSN (print): 1078-0432

ISSN (electronic): 1557-3265

Publisher: American Association for Cancer Research

URL: http://dx.doi.org/10.1158/1078-0432.CCR-14-0511

DOI: 10.1158/1078-0432.CCR-14-0511

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