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Is alternative cardiac surgery an option in adults with congenital heart disease referred for thoracic organ transplantation?

Lookup NU author(s): Dr David Crossland, Dr John O'Sullivan, Dr Stephan Schueler


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OBJECTIVES: We analysed the outcomes of adults with congenital heart disease (ACHD) referred for thoracic organ transplantation who underwent non-transplant cardiac surgery as an alternative management option.METHODS: Adult patients with congenital heart disease assessed for heart or heart-lung transplant were identified from the departmental database. A retrospective analysis of the medical records, transplant assessment data and surgical notes was carried out.RESULTS: One hundred and twenty-six patients were assessed between January 2000 and July 2011. Non-transplant cardiac surgery was performed in 14 (11%) patients. There were nine males with a median age of 37 years (range 21-42). The patients can be divided into four subgroups [left-sided lesions (n = 4), right-sided lesions (n = 3), systemic right ventricle (n = 5) and Fontan circulation (n = 2)]. Surgical procedures performed were: relief of systemic obstructive/regurgitant lesions +/- endocardial fibroelastosis resection (n = 4, three pulmonary vascular resistance >6 Wood units), correction of right-sided regurgitant/stenotic lesions (n = 3), ventricular assist device for patients with a systemic right ventricle (n = 5) and re-fashioning of the Fontan pathway (n = 2). There were two early (5 and 30 days) and three late deaths (64, 232 and 374 days) with a 1-year mortality of 28%. None of the deaths occurred in patients with a two-ventricle circulation and atrio-ventricular concordance. Nine patients are alive at a median of 433 days (range 204-2456). The New York Heart Association class has improved in all survivors by at least one class at 3 and 6 months (P = 0.004 and 0.003).CONCLUSIONS: Alternative cardiac surgery can be undertaken in selected patients with ACHD referred for cardiopulmonary transplantation with a low mortality in patients with two ventricles and a systemic left ventricle. Ventricular assist devices carry a significant mortality in patients with a systemic right ventricle, although this offers a valuable palliation when there are no other options. The medium and long-term results are awaited.

Publication metadata

Author(s): Harper AR, Crossland DS, Perri G, O'Sullivan JJ, Chaudhari MP, Schueler S, Griselli M, Hasan A

Publication type: Article

Publication status: Published

Journal: European Journal of Cardio-Thoracic Surgery

Year: 2013

Volume: 43

Issue: 2

Pages: 344-351

Print publication date: 01/02/2013

Online publication date: 15/05/2012

Acceptance date: 12/05/2012

ISSN (print): 1010-7940

ISSN (electronic): 1873-734X

Publisher: Oxford University Press


DOI: 10.1093/ejcts/ezs240


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