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Lookup NU author(s): Emeritus Professor Brian Diffey
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A mathematical model is described for estimating changes in plasma 25-hydroxyvitamin D (25(OH) D) levels throughout the year as a consequence of varying the oral intake of vitamin D and the behaviour outdoors of white British adults resident in different regions of the UK. The model yields seasonal and geographical patterns of 25(OH) D concentrations that agree closely with observational studies. Use of the model allows estimates to be easily made of the sun exposure and oral intake necessary to avoid vitamin D deficiency in defined proportions of the population, as well as strategies that would lead to vitamin D sufficiency throughout the year. The analysis demonstrates that addressing concerns about insufficient vitamin D levels, especially during the winter, may be achieved by modifying oral vitamin D intake over the winter, increasing summer sun exposure or a combination of both.
Author(s): Diffey BL
Publication type: Article
Publication status: Published
Journal: British Journal of Nutrition
Print publication date: 28/08/2013
Online publication date: 23/01/2013
Acceptance date: 09/11/2012
ISSN (print): 0007-1145
ISSN (electronic): 1475-2662
Publisher: Cambridge University Press
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