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Modelling vitamin D status due to oral intake and sun exposure in an adult British population

Lookup NU author(s): Emeritus Professor Brian Diffey


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A mathematical model is described for estimating changes in plasma 25-hydroxyvitamin D (25(OH) D) levels throughout the year as a consequence of varying the oral intake of vitamin D and the behaviour outdoors of white British adults resident in different regions of the UK. The model yields seasonal and geographical patterns of 25(OH) D concentrations that agree closely with observational studies. Use of the model allows estimates to be easily made of the sun exposure and oral intake necessary to avoid vitamin D deficiency in defined proportions of the population, as well as strategies that would lead to vitamin D sufficiency throughout the year. The analysis demonstrates that addressing concerns about insufficient vitamin D levels, especially during the winter, may be achieved by modifying oral vitamin D intake over the winter, increasing summer sun exposure or a combination of both.

Publication metadata

Author(s): Diffey BL

Publication type: Article

Publication status: Published

Journal: British Journal of Nutrition

Year: 2013

Volume: 110

Issue: 3

Pages: 569-577

Print publication date: 28/08/2013

Online publication date: 23/01/2013

Acceptance date: 09/11/2012

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University Press


DOI: 10.1017/S0007114512005466


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