Toggle Main Menu Toggle Search

Open Access padlockePrints

Synthesis of 3 '-deoxy-3'-fluorothymidine (FLT) 5 '-O-glucuronide: a reference standard for imaging studies with [18F]FLT

Lookup NU author(s): Dr Suzannah HarnorORCiD, Dr Tommy Rennison, Dr Martin Galler, Dr Celine CanoORCiD, Professor Roger Griffin, Professor Herbie Newell, Emeritus Professor Bernard Golding


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Reaction of methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-alpha-D-glucopyranuronate with 3'-deoxy-3'-fluorothymidine in the presence of trimethylsilyl trifluoromethanesulfonate gave (2R,3R,4S,5S,6S)2-((( 2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-methoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate, which was hydrolysed to 3'-deoxy-3'-fluorothymidine-5'-glucuronide. Analysis of this reference standard by high performance liquid chromatography enabled the identification of [F-18]3'-deoxy-3'-fluorothymidine-5'-glucuronide in blood samples from six human patients who had been administered [F-18]3'-deoxy-3'-fluorothymidine.

Publication metadata

Author(s): Harnor SJ, Rennison T, Galler M, Cano C, Griffin RJ, Newell DR, Golding BT

Publication type: Article

Publication status: Published

Journal: MedChemComm

Year: 2014

Volume: 5

Issue: 7

Pages: 984-988

Print publication date: 01/01/2014

ISSN (print): 2040-2503

ISSN (electronic): 2040-2511

Publisher: Royal Society of Chemistry


DOI: 10.1039/c3md00381g


Altmetrics provided by Altmetric