Lookup NU author(s): Jonna Nilsson,
Professor Alan Thomas,
Professor John O'Brien,
Dr Peter Gallagher
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
White matter (WM) change plays an important role in age-related cognitive decline. In this review, we consider methodological advances with particular relevance to the role of WM in age-related changes in processing speed. In this context, intra-individual variability in processing speed performance has emerged as a sensitive proxy of cognitive and neurological decline while neuroimaging techniques used to assess WM change have become increasingly more sensitive. Together with a carefully designed task protocol, we emphasize that the combined implementation of intra-individual variability and neuroimaging techniques hold promise for specifying the WM-processing speed relationship with implications for normative and clinical samples.
Author(s): Nilsson J, Thomas AJ, O'Brien JT, Gallagher P
Publication type: Review
Publication status: Published
Journal: Journal of the International Neuropsychological Society
Print publication date: 01/03/2014
Online publication date: 17/02/2014
Acceptance date: 13/12/2013
ISSN (print): 1355-6177
ISSN (electronic): 1469-7661
Publisher: CAMBRIDGE UNIV PRESS