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Mitochondrial protein synthesis: Figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation

Lookup NU author(s): Professor Robert Lightowlers, Dr Agata Rozanska, Professor Zofia Chrzanowska-LightowlersORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Mitochondrial protein synthesis is essential for all mammals, being responsible for providing key components of the oxidative phosphorylation complexes. Although only thirteen different polypeptides are made, the molecular details of this deceptively simple process remain incomplete. Central to this process is a non-canonical ribosome, the mitoribosome, which has evolved to address its unique mandate. In this review, we integrate the current understanding of the molecular aspects of mitochondrial translation with recent advances in structural biology. We identify numerous key questions that we will need to answer if we are to increase our knowledge of the molecular mechanisms underlying mitochondrial protein synthesis. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Publication metadata

Author(s): Lightowlers RN, Rozanska A, Chrzanowska-Lightowlers ZM

Publication type: Review

Publication status: Published

Journal: FEBS Letters

Year: 2014

Volume: 588

Issue: 15

Pages: 2496-2503

Print publication date: 01/08/2014

Online publication date: 06/06/2014

Acceptance date: 29/05/2014

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468



DOI: 10.1016/j.febslet.2014.05.054