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Lookup NU author(s): Professor Julia NewtonORCiD,
Dr Simon Kerr,
Dr Andrew McLaren,
Professor Rose Anne Kenny,
Dr Christopher Morris
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Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members.
Author(s): Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM
Publication type: Article
Publication status: Published
Journal: American Journal of Medical Genetics: Part A
ISSN (print): 1552-4825
ISSN (electronic): 1552-4833
Publisher: John Wiley & Sons, Inc.