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Hypersensitivity Pneumonitis in Workers Exposed to Metalworking Fluids

Lookup NU author(s): Emeritus Professor David Hendrick

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Abstract

Background This study used data from a large UK outbreak investigation, to develop and validate a new case definition for hypersensitivity pneumonitis due to metalworking fluid exposure (MWF-HP).Methods The clinical data from all workers with suspected MWF-HP were reviewed by an experienced panel of clinicians. A new MWF-HP Score was then developed to match the "gold standard" clinical opinion as closely as possible, using standard diagnostic criteria that were relatively weighted by their positive predictive value.Results The new case definition was reproducible, and agreed with expert panel opinion in 30/37 cases. This level of agreement was greater than with any of the three previously utilized case definitions (agreement in 16-24 cases). Where it was possible to calculate, the MWF-HP Score also performed well when applied to 50 unrelated MWF-HP cases.Conclusions The MWF-HP Score offers a new case definition for use in future outbreaks. (C) 2014 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.

Publication metadata

Author(s): Barber CM, Burton CM, Hendrick DJ, Pickering CAC, Robertson AS, Robertson W, Burge PS

Publication type: Article

Publication status: Published

Journal: American Journal of Industrial Medicine

Year: 2014

Volume: 57

Issue: 8

Pages: 872-880

Print publication date: 01/08/2014

Online publication date: 20/06/2014

Acceptance date: 30/03/2014

Date deposited: 16/10/2014

ISSN (print): 0271-3586

ISSN (electronic): 1097-0274

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/ajim.22337

DOI: 10.1002/ajim.22337

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