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Lookup NU author(s): Professor David Burn
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The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. Moreover, disorders that were thought to be caused by dysfunction of the basal ganglia only, such as Parkinson's disease and Huntington's disease, have diverse abnormalities distributed not only in the brain but also in the peripheral and autonomic nervous systems; this knowledge poses new questions and challenges. We discuss advances and the unanswered questions, and ways in which progress might be made.
Author(s): Obeso JA, Rodriguez-Oroz MC, Stamelou M, Bhatia KP, Burn DJ
Publication type: Article
Publication status: Published
Print publication date: 09/08/2014
Online publication date: 18/06/2014
ISSN (print): 0140-6736
ISSN (electronic): 1474-547X
Publisher: The Lancet Publishing Group
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