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Lookup NU author(s): Monica Piatek,
Dr Andreas Werner
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Endo-siRNAs (endogenous small-interfering RNAs) have recently emerged as versatile regulators of gene expression. They derive from double-stranded intrinsic transcripts and are processed by Dicer and associate with Argonaute proteins. In Caenorhabditis elegans, endo-siRNAs are known as 22G and 26G RNAs and are involved in genome protection and gene regulation. Drosophila melanogaster endo-siRNAs are produced with the help of specific Dicer and Argonaute isoforms and play an essential role in transposon control and the protection from viral infections. Biological functions of endo-siRNAs in vertebrates include repression of transposable elements and chromatin organization, as well as gene regulation at the transcriptional and post-transcriptional levels.
Author(s): Piatek MJ, Werner A
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/08/2014
Acceptance date: 28/03/2014
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press
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