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Endogenous siRNAs: regulators of internal affairs

Lookup NU author(s): Monica Piatek, Dr Andreas Werner

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Abstract

Endo-siRNAs (endogenous small-interfering RNAs) have recently emerged as versatile regulators of gene expression. They derive from double-stranded intrinsic transcripts and are processed by Dicer and associate with Argonaute proteins. In Caenorhabditis elegans, endo-siRNAs are known as 22G and 26G RNAs and are involved in genome protection and gene regulation. Drosophila melanogaster endo-siRNAs are produced with the help of specific Dicer and Argonaute isoforms and play an essential role in transposon control and the protection from viral infections. Biological functions of endo-siRNAs in vertebrates include repression of transposable elements and chromatin organization, as well as gene regulation at the transcriptional and post-transcriptional levels.

Publication metadata

Author(s): Piatek MJ, Werner A

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2014

Volume: 42

Pages: 1174-1179

Print publication date: 01/08/2014

Acceptance date: 28/03/2014

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press

URL: http://dx.doi.org/10.1042/BST20140068

DOI: 10.1042/BST20140068

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