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Motoric cognitive risk syndrome: Multicountry prevalence and dementia risk

Lookup NU author(s): Dr Susan Lord, Professor Lynn Rochester


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Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline >= 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores >= 25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.

Publication metadata

Author(s): Verghese J, Annweiler C, Ayers E, Barzilai N, Beauchet O, Bennett DA, Bridenbaugh SA, Buchman AS, Callisaya ML, Camicioli R, Capistrant B, Chatterji S, De Cock AM, Ferrucci L, Giladi N, Guralnik JM, Hausdorff JM, Holtzer R, Kim KW, Kowal P, Kressig RW, Lim JY, Lord S, Meguro K, Montero-Odasso M, Muir-Hunter SW, Noone ML, Rochester L, Srikanth V, Wang CL

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2014

Volume: 83

Issue: 8

Pages: 718-726

Print publication date: 01/08/2014

Online publication date: 16/07/2014

Acceptance date: 12/05/2014

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1212/WNL.0000000000000717


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Funder referenceFunder name
American Federation for Aging Research
Department of Health
Einstein Glenn Center
Illinois Department of Public Health
Paul Glenn Foundation
Kurihara, Miyagi, Japan
UK NIHR Biomedical Research Centre for Ageing and Age-Related Disease award
04034785WHO (OGHA)
1R21AG034263WHO (OGHA)
2009-A00533-54French Ministry of Health (Projet Hospitalier de Recherche Clinique national)
263 MD 821336NIH
403000Australian National Health and Medical Research Council
2012-0000999National Research Foundation of Korea
263 MD 916413NIH
A092077Korean Health Technology R D Project
A070001Korean Health Technology R D Project
ICS 110.1/RS97.71Italian Ministry of Health
MOP 211220Canadian Institutes of Health and Research
J-0802Parkinson's UK programme grant
R01 AG034479WHO (OGHA)
R01 AG039330NIH
RO3 AG026106NIH
RO1 AG10939NIH
Y1-AG-1005-01WHO (OGHA)
YA1323-08-CN-0020WHO (OGHA)