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Peptidoglycan N-Acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae

Lookup NU author(s): Professor Waldemar Vollmer

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Abstract

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

Publication metadata

Author(s): Vollmer W, Tomasz A

Publication type: Article

Publication status: Published

Journal: Infection and Immunity

Year: 2002

Volume: 70

Issue: 12

Pages: 7176-7178

ISSN (print): 0019-9567

ISSN (electronic): 1098-5522

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/IAI.70.12.7176-7178.2002

DOI: 10.1128/IAI.70.12.7176-7178.2002

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