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The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Peptidoglycan N-Acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae

Lookup NU author(s): Professor Waldemar Vollmer

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Abstract

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

Publication metadata

Author(s): Vollmer W, Tomasz A

Publication type: Article

Publication status: Published

Journal: Infection and Immunity

Year: 2002

Volume: 70

Issue: 12

Pages: 7176-7178

ISSN (print): 0019-9567

ISSN (electronic): 1098-5522

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/IAI.70.12.7176-7178.2002

DOI: 10.1128/IAI.70.12.7176-7178.2002

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