ePrints

Molecular Epidemiology of NDM-1-Producing Enterobacteriaceae and Acinetobacter baumannii Isolates from Pakistan

Lookup NU author(s): Dr Muhammad Raza, Dr John Perry

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The molecular epidemiology of 66 NDM-producing isolates from 2 Pakistani hospitals was investigated, with their genetic relatedness determined using repetitive sequence-based PCR (Rep-PCR). PCR-based replicon typing and screening for antibiotic resistance genes encoding carbapenemases, other beta-lactamases, and 16S methylases were also performed. Rep-PCR suggested a clonal spread of Enterobacter cloacae and Escherichia coli. A number of plasmid replicon types were identified, with the incompatibility A/C group (IncA/C) being the most common (78%). 16S methylase-encoding genes were coharbored in 81% of NDM-producing Enterobacteriaceae.

Publication metadata

Author(s): Sartor AL, Raza MW, Abbasi SA, Day KM, Perry JD, Paterson DL, Sidjabata HE

Publication type: Article

Publication status: Published

Journal: Antimicrobial Agents and Chemotherapy

Year: 2014

Volume: 58

Issue: 9

Pages: 5589-5593

Print publication date: 01/09/2014

Online publication date: 30/06/2014

Acceptance date: 21/06/2014

ISSN (print): 0066-4804

ISSN (electronic): 1098-6596

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/AAC.02425-14

DOI: 10.1128/AAC.02425-14

Altmetrics

Share