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Lookup NU author(s): Dr Muhammad Raza, Dr John Perry
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The molecular epidemiology of 66 NDM-producing isolates from 2 Pakistani hospitals was investigated, with their genetic relatedness determined using repetitive sequence-based PCR (Rep-PCR). PCR-based replicon typing and screening for antibiotic resistance genes encoding carbapenemases, other beta-lactamases, and 16S methylases were also performed. Rep-PCR suggested a clonal spread of Enterobacter cloacae and Escherichia coli. A number of plasmid replicon types were identified, with the incompatibility A/C group (IncA/C) being the most common (78%). 16S methylase-encoding genes were coharbored in 81% of NDM-producing Enterobacteriaceae.
Author(s): Sartor AL, Raza MW, Abbasi SA, Day KM, Perry JD, Paterson DL, Sidjabata HE
Publication type: Article
Publication status: Published
Journal: Antimicrobial Agents and Chemotherapy
Year: 2014
Volume: 58
Issue: 9
Pages: 5589-5593
Print publication date: 01/09/2014
Online publication date: 30/06/2014
Acceptance date: 21/06/2014
ISSN (print): 0066-4804
ISSN (electronic): 1098-6596
Publisher: American Society for Microbiology
URL: http://dx.doi.org/10.1128/AAC.02425-14
DOI: 10.1128/AAC.02425-14
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