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Does cognitive impairment influence outcomes from cataract surgery? Results from a 1-year follow-up cohort study

Lookup NU author(s): Dr Jo Jefferis, Professor John-Paul TaylorORCiD, Michael Clarke



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


BACKGROUND/AIMS: To assess the impact of impaired cognition on visual outcomes 1 year following cataract surgery in a cohort of older people.METHODS: Participants aged 75 years or more with bilateral cataract and scheduled for cataract surgery were recruited consecutively. Cognition was assessed using the revised Addenbrooke's cognitive examination (ACE-R). Participants were divided into two groups: normal (ACE-R ≥88) and impaired cognition (ACE-R <88). Visual quality of life (VQOL) and logarithm of minimum angle of resolution visual acuity (VA) were assessed at baseline and 1 year following cataract surgery.RESULTS: Of 112 participants, 48 (43%) had normal cognition and 64 (57%) had impaired cognition. One year following cataract surgery participants in both groups had significant improvements in VQOL and VA. Visual outcomes at 1 year were significantly better in participants with normal cognition than in those with impaired cognition (95% CIs for difference 0.4-7.0 and 0.02-0.1, for VQOL and VA, respectively). Regression analyses correcting for potential confounders showed a relationship between baseline cognition and VA at 1 year (R2=0.30, p=0.001) and a possible relationship between baseline cognition and VQOL at 1 year (R2=0.41, p=0.01, this became insignificant after removal of outliers).CONCLUSIONS: Patients with impaired cognition benefit from cataract surgery, but not to the same extent as patients with normal cognition

Publication metadata

Author(s): Jefferis JM, Taylor J-P, Clarke MP

Publication type: Article

Publication status: Published

Journal: British Journal of Ophthalmology

Year: 2014

Volume: 99

Issue: 3

Pages: 412-417

Print publication date: 01/03/2015

Online publication date: 06/10/2014

Acceptance date: 25/08/2014

Date deposited: 10/12/2014

ISSN (print): 0007-1161

ISSN (electronic): 1468-2079

Publisher: BMJ Group


DOI: 10.1136/bjophthalmol-2014-305657

PubMed id: 25287367


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Funder referenceFunder name
Dementias and Neurodegenerative Diseases Research Network (DeNDRoN)
088441/Z/09/ZWellcome Trust