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The Effects of Bariatric Surgery on Colorectal Cancer Risk: Systematic Review and Meta-analysis

Lookup NU author(s): Sorena Afshar, Seamus Kelly, Dr Jose Lara-Gallegos, Professor John Mathers

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Abstract

Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58-0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.

Publication metadata

Author(s): Afshar S, Kelly SB, Seymour K, Lara J, Woodcock S, Mathers JC

Publication type: Review

Publication status: Published

Journal: Obesity Surgery

Year: 2014

Volume: 24

Issue: 10

Pages: 1793-1799

Print publication date: 01/10/2014

Online publication date: 12/07/2014

ISSN (print): 0960-8923

ISSN (electronic): 1708-0428

Publisher: SPRINGER

URL: http://dx.doi.org/10.1007/s11695-014-1359-y

DOI: 10.1007/s11695-014-1359-y

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