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Lookup NU author(s): Sorena Afshar,
Dr Jose Lara-Gallegos,
Professor John Mathers
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Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58-0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.
Author(s): Afshar S, Kelly SB, Seymour K, Lara J, Woodcock S, Mathers JC
Publication type: Review
Publication status: Published
Journal: Obesity Surgery
Print publication date: 01/10/2014
Online publication date: 12/07/2014
ISSN (print): 0960-8923
ISSN (electronic): 1708-0428