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Does metergoline selectively attenuate 5-HT mediated prolactin release?

Lookup NU author(s): Dr Sasha Gartside


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Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agent d-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 micrograms/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.

Publication metadata

Author(s): Ellis PM, Gartside SE, Ware CJ, Campling GM, Cowen PJ

Publication type: Article

Publication status: Published

Journal: Psychopharmacology (Berl)

Year: 1991

Volume: 105

Issue: 1

Pages: 129-131

Print publication date: 01/03/1991

ISSN (print): 0033-3158

ISSN (electronic): 1432-2072

Publisher: Springer


DOI: 10.1007/BF02316875

Notes: 0033-3158 (Print) Journal Article


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