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Lookup NU author(s): Dr Sasha Gartside
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Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agent d-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 micrograms/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.
Author(s): Ellis PM, Gartside SE, Ware CJ, Campling GM, Cowen PJ
Publication type: Article
Publication status: Published
Journal: Psychopharmacology (Berl)
Print publication date: 01/03/1991
ISSN (print): 0033-3158
ISSN (electronic): 1432-2072
Notes: 0033-3158 (Print)
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