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Selective 5-HT1A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments

Lookup NU author(s): Dr Sasha Gartside


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The 5-HT receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) produced dose-dependent increases in plasma adrenocorticotropin (ACTH) in the male rat by activation of 5-HT1A and 5-HT2 receptors respectively. The ACTH response to DOI was enhanced by repeated administration of electroconvulsive shock (five over 10 days) but abolished by the tricyclic antidepressant, amitriptyline (20 mg/kg for 14 days). In contrast 21 days lithium treatment failed to alter DOI-induced ACTH release. Neither repeated electroconvulsive shock, nor amitriptyline, nor lithium altered the ACTH response to 8-OH-DPAT. These data are consistent with results from ligand binding and behavioural studies which suggest that the sensitivity of brain 5-HT2 receptors is increased by repeated electroconvulsive shock but attenuated by tricyclic antidepressant treatment. In contrast, our data suggest that the antidepressant treatments studied do not alter the sensitivity of the 5-HT1A receptors involved in ACTH release.

Publication metadata

Author(s): Gartside SE, Ellis PM, Sharp T, Cowen PJ

Publication type: Article

Publication status: Published

Journal: European Journal of Pharmacology

Year: 1992

Volume: 221

Issue: 1

Pages: 27-33

Print publication date: 06/10/1992

ISSN (print): 0014-2999

ISSN (electronic): 1879-0712

Publisher: Elsevier


DOI: 10.1016/0014-2999(92)90768-Y

Notes: 0014-2999 (Print) Journal Article


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