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Developing an international Pseudomonas aeruginosa reference panel

Lookup NU author(s): Professor Anthony De SoyzaORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

Publication metadata

Author(s): De Soyza A; Hall AJ; Mahenthiralingam E; Drevinek P; Kaca W; Drulis-Kawa Z; Stoitsova SR; Toth V; Coenye T; Zlosnik JEA; Burns JL; Sa-Correia I; De Vos D; Pirnay JP; Kidd TJ; Reid D; Manos J; Klockgether J; Wiehlmann L; Tummler B; McClean S; Winstanley C

Publication type: Article

Publication status: Published

Journal: MicrobiologyOpen

Year: 2013

Volume: 2

Issue: 6

Pages: 1010-1023

Print publication date: 01/12/2013

Online publication date: 11/11/2013

Date deposited: 08/01/2016

ISSN (electronic): 2045-8827

Publisher: Wiley-Blackwell


DOI: 10.1002/mbo3.141

Notes: On behalf of EU FP7 funded COST Action BM1003 "Cell surface virulence determinants of cystic fibrosis pathogens"


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Funder referenceFunder name
Higher Education Funding Council for England Senior Lectureship
NIDDK P30 DK 89507National Institutes of Health