Toggle Main Menu Toggle Search

Open Access padlockePrints

Keeping children safe at home: protocol for a matched case-control study of modifiable risk factors for poisoning

Lookup NU author(s): Emerita Professor Elaine McCollORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background Childhood unintentional and suspected poisonings are a serious public health problem. Evidence from systematic reviews demonstrates that home safety education in combination with safety equipment provision increases the safe storage of medicines and other products. There is lack of evidence that poisoning prevention practices reduce poisoning rates.Objectives To estimate ORs for medically attended poisonings in children aged 0-4 years for items of safety equipment, home hazards and parental safety practices aimed at preventing poisoning, and to explore differential effects by child and family factors.Design Multicentre case-control study in UK hospitals with validation of parent-reported exposures using home observations. Cases are aged 0-4 years with a medically attended poisoning occurring at home, matched on age and sex with community controls. Children attending hospital for other types of injury will serve as unmatched hospital controls. Matched analyses will use conditional logistic regression; unmatched analyses will use unconditional logistic regression to adjust for confounding variables. The study requires 266 poisoning cases and 1064 matched controls to detect an OR of 0.64 for safe storage of medicinal products and of 0.65 for non-medicinal products, with 80% power, a 5% significance level and a correlation between exposures in cases and controls of 0.1.Main outcome measures Unintentional childhood poisoning.Discussion This will be the largest study to date exploring modifiable risk factors for poisoning in young children. Findings will inform: policy makers developing poison prevention strategies, practitioners delivering poison prevention interventions, parents to reduce the risk of poisoning in their homes.

Publication metadata

Author(s): McColl E; Majsak-Newman G; Benford P; Ablewhite J; Clacy R; Coffey F; Cooper N; Coupland C; Hayes M; Kay B; Reading R; Sutton A; Stewart J; Watson MC; Kendrick D

Publication type: Article

Publication status: Published

Journal: Injury Prevention

Year: 2014

Volume: 20

Issue: 5

Print publication date: 01/10/2014

Online publication date: 07/04/2014

Acceptance date: 19/03/2014

ISSN (print): 1353-8047

ISSN (electronic): 1475-5785

Publisher: BMJ Publishing Group


DOI: 10.1136/injuryprev-2014-041234


Altmetrics provided by Altmetric


Funder referenceFunder name
RP-PG-0407-10231National Institute for Health Research (NIHR)