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Evidence that the large neutral amino acid L-valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo

Lookup NU author(s): Dr Sasha Gartside


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L-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect of L-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which received L-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate that L-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo.

Publication metadata

Author(s): Gartside SE, Cowen PJ, Sharp T

Publication type: Article

Publication status: Published

Journal: Psychopharmacology (Berl)

Year: 1992

Volume: 109

Issue: 1-2

Pages: 251-253

Print publication date: 01/10/1992

ISSN (print): 0033-3158

ISSN (electronic): 1432-2072

Publisher: Springer


DOI: 10.1007/BF02245511

Notes: 0033-3158 (Print) Journal Article


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