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Lookup NU author(s): Dr Sasha Gartside
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L-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect of L-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which received L-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate that L-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo.
Author(s): Gartside SE, Cowen PJ, Sharp T
Publication type: Article
Publication status: Published
Journal: Psychopharmacology (Berl)
Print publication date: 01/10/1992
ISSN (print): 0033-3158
ISSN (electronic): 1432-2072
Notes: 0033-3158 (Print)
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