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Predicting age across human lifespan based on structural connectivity from diffusion tensor imaging

Lookup NU author(s): Dr Luis Peraza RodriguezORCiD, Professor John-Paul TaylorORCiD, Professor Marcus Kaiser


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Predicting brain maturity using noninvasive magnetic resonance images (MRI) can distinguish different age groups and help to assess neurodevelopmental disorders. However, group-wise differences are often less informative for assessing features of individuals. Here, we propose a simple method to predict the age of an individual subject solely based on structural connectivity data from diffusion tensor imaging (DTI). Our simple predictor computes a weighted sum of connection strengths of an individual, where weights are the importance of that connection for an observed feature—age in this case. The weights are simply determined through correlations between connection strength and age; thus the proposed predictor requires no parameter tuning. We tested this approach using DTI data from 201 healthy subjects aged 4 to 85 years. After determining importance in a training dataset, our predicted ages in the test dataset showed a strong correlation (r = 0.79) with real age deviating by, on average, only about 9 years.

Publication metadata

Author(s): Han CE, Peraza LR, Taylor J-P, Kaiser M

Editor(s): IEEE

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 2014 IEEE Biomedical Circuits and Systems Conference (BioCAS)

Year of Conference: 2014

Pages: 137-140

Online publication date: 11/12/2014

Acceptance date: 01/01/1900

ISSN: 1940-9990

Publisher: IEEE


DOI: 10.1109/BioCAS.2014.6981664

Library holdings: Search Newcastle University Library for this item

ISBN: 9781479923465