Browse by author
Lookup NU author(s): Dr Sarah Steven, Dr Peter Carey, Professor Roy Taylor
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
AimTo define the impact of duration of diabetes and extent of weight loss on the reversibility of Type 2 diabetes after bariatric surgery.MethodsComplete data were collated from 89 individuals with Type 2 diabetes mellitus undergoing any bariatric surgical procedure in a specialist bariatric centre. People with a preoperative HbA(1c) < 43 mmol/mol (6.1%) were excluded. Diabetes duration was defined as: short, <4 years; medium, 4-8 years; and long, >8 years.ResultsAn HbA(1c) of <43mmol/mol (6.1%) was achieved by 62% of patients in the short-duration group and 26% of patients in the long-duration group. Normoglycaemia was rarely achieved in the long-duration group if weight loss was < 25kg. In the whole cohort there was a clear relationship of greater weight loss with lower HbA(1c) levels (R-s = -0.53; P<0.0001).ConclusionsThe study shows that the degree of achieved weight loss is the major determinant of return to normal blood glucose levels after bariatric surgery. Normoglycaemia can be achieved in long-duration Type 2 diabetes, but a greater degree of weight loss is required than for short-duration diabetes.What's new? The interaction between duration of diabetes and extent of weight loss in defining diabetes reversal after bariatric surgery has not previously been investigated in a cohort representative of the heterogeneous population undergoing bariatric surgery with a clinically verified diagnosis of Type 2 diabetes. These data have implications for clinical practice, in particular for the selection of patients for bariatric surgery but, more generally, for our understanding of the pathophysiology of Type 2 diabetes.
Author(s): Steven S, Carey PE, Small PK, Taylor R
Publication type: Article
Publication status: Published
Journal: Diabetic Medicine
Year: 2015
Volume: 32
Issue: 1
Pages: 47-53
Print publication date: 01/01/2015
Online publication date: 12/09/2014
Acceptance date: 16/08/2014
ISSN (print): 0742-3071
ISSN (electronic): 1464-5491
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1111/dme.12567
DOI: 10.1111/dme.12567
Altmetrics provided by Altmetric