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Lookup NU author(s): Emeritus Professor John Davison
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Successful pregnancies have been reported in all types of solidorgan transplant recipients on a variety of immunosuppressive regimens. Immunosuppression is essential to maintain the transplanted organ and maternal health, thus the safety of these medications continues to be studied. This article reviews information in the literature and data from the National Trans-, plantation Pregnancy Registry (NTPR) in the United States related to immunosuppressive medication and pregnancy. Although most maintenance immunosuppressive regimens have not been shown to affect the outcome of posttransplant pregnancies, mycophenolic acid products are associated with an increased incidence of spontaneous abortion and an increase in the incidence and a specific pattern of birth defects. When counseling transplant recipients about the prospect and safety of pregnancy, the health of the mother, her graft, and the developing fetus must all be taken into account. (C) 2014 Elsevier Ltd. All rights reserved.
Author(s): Coscia LA, Constantinescu S, Davison JM, Moritz MJ, Armenti VT
Publication type: Article
Publication status: Published
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology
Print publication date: 01/11/2014
Online publication date: 07/08/2014
ISSN (print): 1521-6934
ISSN (electronic): 1532-1932
Publisher: ELSEVIER SCI LTD
PubMed id: 25175414
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