Toggle Main Menu Toggle Search

Open Access padlockePrints

Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

Lookup NU author(s): Dr Zakareya Gamie

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Introduction: Mesenchymal stem cells (MSCs) can be obtained from a wide variety of tissues for bone tissue engineering such as bone marrow, adipose, birth-associated, peripheral blood, periosteum, dental and muscle. MSCs from human fetal bone marrow and embryonic stem cells (ESCs) are also promising cell sources.Areas covered: In vitro, in vivo and clinical evidence was collected using MEDLINE (R) (1950 to January 2014), EMBASE (1980 to January 2014) and Google Scholar (1980 to January 2014) databases.Expert opinion: Enhanced results have been found when combining bone marrow-derived mesenchymal stem cells (BMMSCs) with recently developed scaffolds such as glass ceramics and starch-based polymeric scaffolds. Preclinical studies investigating adipose tissue-derived stem cells and umbilical cord tissue-derived stem cells suggest that they are likely to become promising alternatives. Stem cells derived from periosteum and dental tissues such as the periodontal ligament have an osteogenic potential similar to BMMSCs. Stem cells from human fetal bone marrow have demonstrated superior proliferation and osteogenic differentiation than perinatal and postnatal tissues. Despite ethical concerns and potential for teratoma formation, developments have also been made for the use of ESCs in terms of culture and ideal scaffold.


Publication metadata

Author(s): Gamie Z, MacFarlane RJ, Tomkinson A, Moniakis A, Tran GT, Gamie Y, Mantalaris A, Tsiridis E

Publication type: Review

Publication status: Published

Journal: Expert Opinion on Biological Therapy

Year: 2014

Volume: 14

Issue: 11

Pages: 1611-1639

Print publication date: 01/11/2014

ISSN (print): 1471-2598

ISSN (electronic): 1744-7682

Publisher: INFORMA HEALTHCARE

URL: http://dx.doi.org/10.1517/14712598.2014.945414

DOI: 10.1517/14712598.2014.945414


Share