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Regan isoenzyme of alkaline phosphatase as a tumour marker for renal cell carcinoma

Lookup NU author(s): Dr Jakub Bukowczan, Dr Fiona Jenkinson, Dr Richard Quinton

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Abstract

Alkaline phosphatase is an enzyme present in all tissues of the human body. Several isoforms of this enzyme have been described with different catalytic nature, stability and antigenic structure. Rises in the activity of alkaline phosphatase are recognised in various states including bone diseases, liver disease, pregnancy, hyperthyroidism and malignant processes. The Regan isoenzyme, a rare variant of placental alkaline phosphatase, has been identified circulating in association with various tumours. The reported case describes a rising Regan isoform of alkaline phosphatase concentrations that led to a new diagnosis of occult renal cell carcinoma and persistently elevated activity postoperatively signposting persistent or recurrent disease.

Publication metadata

Author(s): Bukowczan J, Pattman S, Jenkinson F, Quinton R

Publication type: Article

Publication status: Published

Journal: Annals of Clinical Biochemistry

Year: 2014

Volume: 51

Issue: 5

Pages: 611-614

Print publication date: 01/09/2014

Online publication date: 10/03/2014

Acceptance date: 08/02/2014

ISSN (print): 0004-5632

ISSN (electronic): 1758-1001

Publisher: Sage Publications

URL: http://dx.doi.org/10.1177/0004563214526169

DOI: 10.1177/0004563214526169

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