Browse by author
Lookup NU author(s): Dr John O'Sullivan, Dr David Crossland, Dr Gareth Parry, Dr Guy MacGowanORCiD, Dr Stephan Schueler
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background. The systemic morphologic right ventricle (RV) in congenitally corrected transposition of the great arteries or after atrial switch for transposition of the great arteries is associated with late ventricular failure. Although the role of the left ventricular assist device (LVAD) in supporting the failing LV is established, the indications and outcomes of using LVAD in a systemic RV remain unclear. We assessed the role of a third-generation LVAD for systemic RV support.Methods. Seven patients (mean age, 36 years) received the HeartWare (HeartWare International Inc, Framingham, MA) VAD for systemic RV failure (congenitally corrected transposition of the great arteries in 1 and after atrial switch in 6). Four patients (57%) had severe subpulmonic LV failure, and aggressive perioperative diuresis with or without hemofiltration was used to off-load the subpulmonic LV. The indications of VAD were (1) bridge to transplant in 3 and (2) bridge to decision for a high transpulmonary gradient in 4. Transplantation outcome was compared with systemic RV failure without VAD bridge in 19 patients (years 1989 to 2013).Results. Systemic RV support alone was achieved in all patients, with no early deaths (<= 30 days). Overall, 6 (86%) returned home, 3 (44%) received a transplant, 2 (28%) died of noncardiac causes, and 2 (28%) continue on VAD support (median support, 232 days). Repeat catheterization (n = 4) showed an improved median transpulmonary gradient in 3 patients (median 18.5 mm Hg pre-VAD vs 8.0 mm Hg post-VAD). Two bridge-to-decision patients received transplants at 640 and 685 days. The stroke rate on VAD support was 43% (2 thromboembolic and 1 hemorrhagic; 3 with satisfactory recovery). De novo aortic regurgitation was 29% (n = 2; 1 valve replacement). All patients (n = 3) survived transplantation (vs 10.5% early mortality without VAD bridge; p = 1.00) and were well at follow-up (range, 53 to 700 days).Conclusions. The third-generation VAD provides durable support for systemic RV failure as a bridge to transplant and as a strategy to reduce pulmonary vascular resistance. Although concomitant subpulmonic LV failure is common, systemic RV support alone was achieved in all patients. (C) 2014 by The Society of Thoracic Surgeons
Author(s): Peng E, O'Sullivan JJ, Griselli M, Roysam C, Crossland D, Chaudhari M, Wrightson N, Butt T, Parry G, MacGowan GA, Schueler S, Hasan A
Publication type: Article
Publication status: Published
Journal: Annals of Thoracic Surgery
Year: 2014
Volume: 98
Issue: 6
Pages: 2122-2129
Print publication date: 01/12/2014
Online publication date: 22/10/2014
Acceptance date: 11/06/2014
ISSN (print): 0003-4975
ISSN (electronic): 1552-6259
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.athoracsur.2014.06.054
DOI: 10.1016/j.athoracsur.2014.06.054
Altmetrics provided by Altmetric
