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Lookup NU author(s): Dr Chengyu Liu, Dr James Blake, Dr Ding Chang Zheng
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measured to determine arterial volume distensibility. In comparison with the normal subjects, after adjusting for pulse pressure, baPWV in the BRVO patients was significantly higher by 2.3 m/s (P<0.01) and arterial distensibility was significantly lower by 0.015% per mmHg (P<0.01). No subject in the normal group had an arterial distensibility lower than 0.04% per mmHg, in comparison with 67% (20/30) in the BRVO group. Arterial distensibility was significantly related to systolic and diastolic blood pressures (SBP and DBP) and ageing for both groups (all P<0.05), but in the BRVO group, blood pressures and ageing had more prominent effect on arterial volume distensibility. Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects. The more prominent effect of SBP, DBP and ageing on arterial distensibility indicates the potential underlying mechanisms of the interaction between higher blood pressures, ageing and BRVO disease.
Author(s): Chen ZQ, Mao LN, Liu CY, Blake JR, Zheng DC
Publication type: Article
Publication status: Published
Journal: Scientific Reports
Year: 2014
Volume: 4
Online publication date: 20/10/2014
Acceptance date: 01/10/2014
Date deposited: 23/02/2015
ISSN (electronic): 2045-2322
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/srep06685
DOI: 10.1038/srep06685
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