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Recent advances in the management of graft-versus-host disease

Lookup NU author(s): Professor Mary Slatter, Professor Roderick Skinner


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Graft-versus-host disease (GvHD) remains a significant hurdle in overcoming the morbidity and mortality associated with haemopoietic stem cell transplantation in children. Better understanding of its pathobiology is facilitating the development of biomarkers for the severity of acute GvHD and treatment response, and has led to the introduction of a more prognostically relevant grading system for chronic GvHD. These enable stratification of appropriate prophylactic and treatment strategies according to the risk profiles of individual patients. Steroid-refractory acute GvHD has a poor prognosis, but early reports of the use of new immunosuppressive drugs and especially cellular treatments with extracorporeal photopheresis and mesenchymal stem cells suggest improved short-term outcomes and offer the promise of increased longer-term survival rates.

Publication metadata

Author(s): Dhir S, Slatter M, Skinner R

Publication type: Review

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2014

Volume: 99

Issue: 12

Pages: 1150-1157

Print publication date: 01/12/2014

Online publication date: 12/07/2014

Acceptance date: 23/06/2014

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044



DOI: 10.1136/archdischild-2013-304832