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Ex vivo lung perfusion in clinical lung transplantation-State of the art

Lookup NU author(s): Dr Anders Andreasson, Professor John Dark, Professor Andrew FisherORCiD


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Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic times and potentially improve the outcome of donor lungs already deemed acceptable for transplantation. It took over half a century for the technique to evolve from basic theory to semi-automated circuits fit for clinical use that are now rapidly being adopted in transplant centres across the globe. With this field in constant evolution and many unanswered questions remaining, our review serves as an update on the state of the art of EVLP in clinical lung transplantation.

Publication metadata

Author(s): Andreasson ASI, Dark JH, Fisher AJ

Publication type: Review

Publication status: Published

Journal: European Journal of Cardio-Thoracic Surgery

Year: 2014

Volume: 46

Issue: 5

Pages: 779-788

Print publication date: 01/11/2014

Online publication date: 24/07/2014

Acceptance date: 07/04/2014

ISSN (print): 1010-7940

ISSN (electronic): 1873-734X



DOI: 10.1093/ejcts/ezu228