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Squamous Cell Carcinoma of the Head and Neck Outside the Oropharynx Is Rarely Human Papillomavirus Related

Lookup NU author(s): Professor Philip Sloan, Dr Max RobinsonORCiD


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Objectives/HypothesisThe incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature.Study DesignCase series.MethodsTwo hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control.ResultsAn incidence of 4% of HPV-driven cases was observed across the subsites outside the oropharynx compared to 70% of tumors confined within it.ConclusionsThis is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas.Level of Evidence4 Laryngoscope, 124:2739-2744, 2014

Publication metadata

Author(s): Upile NS, Shaw RJ, Jones TM, Goodyear P, Liloglou T, Risk JM, Boyd MT, Sheard J, Sloan P, Robinson M, Schache AG

Publication type: Article

Publication status: Published

Journal: Laryngoscope

Year: 2014

Volume: 124

Issue: 12

Pages: 2739-2744

Print publication date: 01/12/2014

Online publication date: 18/07/2014

Acceptance date: 16/06/2014

ISSN (print): 0023-852X

ISSN (electronic): 1531-4995

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/lary.24828


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