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Lookup NU author(s): Professor John O'Brien, Dr Michael FirbankORCiD, Dr Christopher Davison, Nicola Barnett, Claire BamfordORCiD, Professor Cam Donaldson, Kirsty OlsenORCiD, Dr David Williams, Dr James LloydORCiD
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Brain imaging with glucose (F-18-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken. Methods: Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and controls (n = 30) underwent F-18-FDG PET and SPECT in balanced order. The main outcome measure was area under the curve (AUC) of receiver-operating-characteristic analysis of visual scan rating. Results: Consensus diagnosis with F-18-FDG PET was superior to SPECT for both dementia vs. no-dementia (AUC = 0.93 vs. 0.72, P = 0.001) and AD vs. DLB (AUC = 0.80 vs. 0.58, P = 0.005) comparisons. The sensitivity and specificity for dementia/no-dementia was 85% and 90%, respectively, for F-18-FDG PET and 71% and 70%, respectively, for SPECT. Conclusion: (F-18-FDG) PET was significantly superior to blood flow SPECT. We recommend F-18-FDG PET be performed instead of perfusion SPECT for the differential diagnosis of degenerative dementia if functional imaging is indicated.
Author(s): O'Brien JT, Firbank MJ, Davison C, Barnett N, Bamford C, Donaldson C, Olsen K, Herholz K, Williams D, Lloyd J
Publication type: Article
Publication status: Published
Journal: Journal of Nuclear Medicine
Year: 2014
Volume: 55
Issue: 12
Pages: 1959-1965
Print publication date: 01/12/2014
Online publication date: 05/11/2014
Date deposited: 04/06/2015
ISSN (print): 0161-5505
ISSN (electronic): 1535-5667
Publisher: Society of Nuclear Medicine
URL: http://dx.doi.org/10.2967/jnumed.114.143347
DOI: 10.2967/jnumed.114.143347
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