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Dynamin protein in stroke and vascular dementia

Lookup NU author(s): Professor Raj Kalaria, Emeritus Professor Elaine Perry

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Abstract

Damage to sub-cortical white matter is a key substrate of vascular dementia (VaD) leading to deficits in executive function and cognitive processing speed. Dynamin1 is a 100 kDa protein, accounting for 0.4% of the total brain protein, and has a central role in many intracellular processes such as synaptic vesicle trafficking and recycling. In this study, we examined the status of Dynamin1 in the white matter from frontal cortex area. In order to measure the levels of Dynamin1, we isolated cortical white matter from a total of 34 post-mortem brains derived from controls (N = 11), mixed Alzheimer's disease (AD) and VaD (N = 8), VaD (N = 7), and stroke no dementia (SND, N = 8) subjects. A commercial ELISA kit was then used to determine the level of Dynamin1. In comparison to controls, Dynamin1 was elevated in patients SND (+400%) and reduced in patients with mixed VaD (-50%). Furthermore, levels of Dynamin1 were significantly associated with preserved cognition as indicated by the MMSE and CAMCOG and upregulation of vesicular glutamate transporter 1. This work indicates that Dynamin1 is associated with both preserved cognition and regenerative responses in older people with cerebrovascular disease and may represent a novel treatment target. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Mulugeta E, Vallortigara J, Francis PT, Hye A, Kalaria RN, Perry EK, Lovestone S, Ballard CG

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2014

Volume: 563

Pages: 118-122

Print publication date: 20/03/2014

Online publication date: 30/01/2014

Acceptance date: 23/01/2014

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd.

DOI: 10.1016/j.neulet.2014.01.045

PubMed id: 24486840


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