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Katayama et al.: Therapeutic Window of Lamotrigine for Mood Disorders: A Naturalistic Retrospective Study. Pharmacopsychiatry 2014; 47: 111-114

Lookup NU author(s): Professor Heinz Grunze

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Abstract

Katayama and colleagues proposed in their article a therapeutic window for lamotrigine in affective disorders between 5 and 11g/mL. Despite potential differences in lamotrigine metabolism, the results of their retrospective study in a Japanese population match nicely with what we have previously reported in a Caucasian population with rapid cycling bipolar disorder. It is suggested that not only in epilepsy, but also in mood-disordered patients clinicians should rather consider lamotrigine plasma levels than dosage when in doubt about the efficacy of treatment.

Publication metadata

Author(s): Grunze H, Walden J

Publication type: Letter

Publication status: Published

Journal: Pharmacopsychiatry

Year: 2014

Volume: 47

Issue: 7

Pages: 268-269

Print publication date: 01/11/2014

ISSN (print): 0176-3679

ISSN (electronic): 1439-0795

Publisher: GEORG THIEME VERLAG KG

URL: http://dx.doi.org/10.1055/s-0034-1390413

DOI: 10.1055/s-0034-1390413

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