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Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins

Lookup NU author(s): Clare Mahon, Dr Tom McAllisterORCiD, Dr David Fulton



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


A conceptually new approach to the design of macromolecular receptors for lectins is outlined. Carbohydrate-functionalised Polymer-Scaffolded Dynamic Combinatorial Libraries (PS-DCLs) have been prepared in aqueous solution by the reversible conjugation of carbohydrates possessing acylhydrazide functionalities in their aglycone on to an aldehyde-functionalised polymer scaffold. PS-DCLs have been shown to undergo compositional change in response to the addition of lectin templates, with polymer scaffolds preferentially incorporating carbohydrate units which recognise the lectin added. This compositional change has been shown to generate polymers of significantly enhanced affinity for the lectin added, with enhancements in free energy of binding in the range of 5.2–8.8 kJ mol−1 observed. Experiments indicate that these enhancements are not only as a consequence of increased display of the preferred carbohydrate upon the polymer scaffold, but that templation also reorganises key residues into strategic positions in order to interact more strongly with the target.

Publication metadata

Author(s): Mahon CS, Fascione MA, Sakonsinsiri CS, McAllister TE, Turnbull WB, Fulton DA

Publication type: Article

Publication status: Published

Journal: Organic & Biomolecular Chemistry

Year: 2015

Volume: 13

Issue: 9

Pages: 2756-2761

Print publication date: 07/03/2015

Online publication date: 09/01/2015

Acceptance date: 08/01/2015

Date deposited: 04/02/2015

ISSN (print): 1477-0520

ISSN (electronic): 1477-0539

Publisher: RSC Publications


DOI: 10.1039/c4ob02587c


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Funder referenceFunder name
CM1102COST action
EP/G043302/1Engineering and Physical Sciences Research Council
EP/G066507/1Engineering and Physical Sciences Research Council